?UNIVERSITY OF MINNESOTA CHILDREN?S HOSPITAL, FAIRVIEW

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Chandy John, M.D., M.S., pediatric infectious disease specialist and director, Center for Global Pediatrics.

Improving the health of children worldwide

Every year more than 700,000 children in sub-Saharan Africa develop cerebral malaria, a disease that affects the brain and leads to fever and coma. As many as 20 percent of children with cerebral malaria die from the disease.

Chandy John, M.D., M.S., pediatric infectious disease specialist and director, Center for Global Pediatrics at the University of Minnesota and colleagues from the University of Minnesota, Makerere University in Uganda and Michigan State University have determined that cerebral malaria is related to long-term cognitive impairment in one of four child survivors. In a study titled, ?Cerebral Malaria in Children is Associated with Long-term Cognitive Impairment,? published in the July 2008 issue of Pediatrics, John and colleagues evaluated cognitive function in areas of attention, working memory and tactile

uofmchildrenshospital.org

January 2009 vol. 3, issue 1 Published bimonthly for health care professionals?Estimated Read Time: 15 minutes learning in children ages 5-12 years old with cerebral malaria in Uganda. Children were evaluated at hospitalization, six months after the initial malaria episode and two years after the initial malaria episode. John and colleagues found that six months after the initial malaria episode, 21 percent of children with cerebral malaria had cognitive impairment compared to 6 percent of healthy children in the community. Two years after the initial malaria episode, 26 percent of children with cerebral malaria had cognitive impairment compared to 8 percent of children in the community. continues inside>>

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